2-Deoxy-D-glucose-抑制剂-深圳欣博盛生物科技有限公司

首页产品中心抑制剂

2-Deoxy-D-glucose

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3681-G001	规格：1 g	目录价：￥600
货号：AG-CR1-3681-G005	规格：5 g	目录价：￥2280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

2-Deoxy-D-glucose

别名:

2-Deoxyglucose; 2-Deoxy-D-arabinohexose; Ba2758; NSC 15293; 2-DG

产品描述:

Non-metabolizable glucose analog. An indirect inhibitor of hexokinase (HK), inhibiting the rate limiting step of glycolysis and consequently decreases glycolysis. Inhibits phosphorylation of glucose by hexokinase, which consequently results in the depletion in cellular ATP, the inhibition of protein glycosylation and the disruption of ER quality control by inducing the unfolded protein response. Useful agent for immunometabolism research. Anticancer agent. Shown to cause in vitro cell cycle inhibition and cell death in models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK and block tumor cell growth in animal models. Potential antiviral agent. 2-Deoxy-D-glucose (2-DG) is potentially useful for COVID-19 treatment due to its effects on the glycolytic pathway, antiinflammatory activity and interaction with viral proteins. 2-DG has previously been shown to be effective against other viruses in cell culture. Blocking glycolysis with non-toxic concentrations of 2-deoxy-D-glucose prevented SARS-CoV-2 replication and viral growth in Caco-2 cells.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

164.2

产品形式:

solid

产地:

瑞士

纯度:

>98%