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折扣/货期| 货号：AG-CR1-3680-M001 | 规格：1 mg | 目录价：￥540 |
| 货号：AG-CR1-3680-M005 | 规格：5 mg | 目录价：￥1740 |
| 货号：AG-CR1-3680-M010 | 规格：10 mg | 目录价：￥2520 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
A-674563 (free base)
别名:
alphaS-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine
产品描述:
A-674563 is a potent, ATP-competitive, reversible and orally available Akt1 inhibitor with an IC50 of 11nM. Binds to the ATP site of the AKT kinase domain, inhibiting AKT-catalyzed phosphorylation activity. Also inhibits PKA and CDK2 with IC50 values of 16nM and 46nM, respectively. 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK and TK families. Anticancer compound. Reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4µM. Shown to decrease tumor growth in mouse tumor xenograft models. Decreased sphingosine kinase 1 (SphK1) activity in AML cells to deplete pro-survival sphingosine-1-phosphate (S1P) and boost pro-apoptotic ceramide production.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
358.4
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
552325-73-2
分子式:
C22H22N4O
促销活动
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