官网链接
折扣/货期| 货号：AG-CR1-3676-M001 | 规格：1 mg | 目录价：￥360 |
| 货号：AG-CR1-3676-M005 | 规格：5 mg | 目录价：￥1440 |
| 货号：AG-CR1-3676-M025 | 规格：25 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
VR23 [Proteasome Inhibitor]
别名:
7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline
产品描述:
Potent selective and reversible chloroquine derivative 20S proteasome inhibitor (all proteolytic subunits). Targets the trypsin-like beta2 subunit of the constitutive 20S proteasome (IC50=1nM). Cross-reacts and inhibits the chymotrypsin-like beta5 subunit (IC50=50-100nM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=3µM). Anticancer compound effective in cell-based assays and against multiple myeloma and metastatic breast cancer in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, as well as in bortezomib-resistent multiple myeloma cells, but with minimal effects on non-cancerous cells.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
477.9
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1624602-30-7
分子式:
C19H16ClN5O6S
溶解度:
Soluble in DMSO (10mg/ml) or DMF. Poorly soluble in aqueous solutions.
促销活动
精品推荐
