Acetylated Lysine Antibody: HRP-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

Acetylated Lysine Antibody: HRP

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-157F

规格：400 µl

目录价：￥5203.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Acetylated Lysine Antibody: HRP

别名:

lysine Antibody, acetyl lysine Antibody

产品描述:

Rabbit Anti-Acetylated Lysine Polyclonal

反应种属:

Species Independent

宿主来源:

Rabbit

实验应用:

WB | ICC/IF | IP | ELISA

靶标/特异性:

Detects proteins containing acetylated lysine residues. No reaction to non-acetylated proteins.

推荐稀释度:

WB (1:250), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Acetylated KLH Conjugated

克隆性:

Polyclonal

纯化方式:

Protein A Purified

偶联:

HRP

产品浓度:

0.25 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anti-cancer drugs currently in development (5).