ACER1 antibody, C-term-多抗-深圳欣博盛生物科技有限公司

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ACER1 antibody, C-term

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX48935

规格：50μg

目录价：￥6300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ACER1 antibody, C-term

别名:

alkaline ceramidase 1 , ALKCDase1 , ASAH3

反应种属:

Human

宿主来源:

Rabbit

实验应用:

同种型:

IgG

免疫原:

A synthetic peptide corresponding to a C-terminal region of Human ACER1

克隆性:

Polyclonal

克隆号:

纯化方式:

Affinity Purified

偶联:

Unconjugated

产品浓度:

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 2% Sucrose, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]

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