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折扣/货期| 货号：GTX73794 | 规格：1ml | 目录价：￥10400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ACTH antibody [AH26]
别名:
proopiomelanocortin , ACTH , CLIP , LPH , MSH , NPP , OBAIRH , POC
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
靶标/特异性:
This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.
同种型:
IgG1
免疫原:
BALB/C mice were injected with a synthetic peptide corresponding to amino acids 1-24 from the N-terminal of human ACTH.
克隆性:
Monoclonal
克隆号:
AH26
纯化方式:
Purified IgG
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
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