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折扣/货期| 货号：GTX82559 | 规格：100μg | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Actin antibody [BA3R]
别名:
PS1TP5BP1 , beta cytoskeletal actin , Beta-actin , Betaactin , actin , beta , PS1TP5-binding protein 1 , actin , cytoplasmic1 , actin , cytoplasmic 1 , PS1TP5binding protein1 , PS1TP5binding protein 1 , Beta actin , PS1TP5 binding protein 1
反应种属:
Chicken, Human, Mouse, Rabbit, Rat
宿主来源:
Mouse
实验应用:
ELISA, ICC/IF, IHC, WB
靶标/特异性:
Recognizes native and denatured forms of β-Actin (∼42kDa)
同种型:
IgG2b
免疫原:
β-Actin N-terminal peptide-KLH conjugates
克隆性:
Monoclonal
克隆号:
BA3R
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is foundin two main states; G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G-and F-actin are intrinsically flexible structures - a feature vital in actin's role as a dynamic filamentnetwork. Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actinis a component of the cytoskeleton and links to alpha-actinin, E-cadherin and beta-catenin at adherensjunctions. This gives mechanical support to cells and attaches them to each other and the extracellularmatrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to formactomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening throughactin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has arole in cell motility through polymerization and depolymerization of fibrils.
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