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折扣/货期| 货号：AG-CR1-3903-M001 | 规格：1 mg | 目录价：￥480 |
| 货号：AG-CR1-3903-M005 | 规格：5 mg | 目录价：￥1440 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ACY-775
别名:
2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
产品描述:
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µM). Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900). Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones. Shows antidepressant activity. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
330.4
产品形式:
solid
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
1375466-18-4
分子式:
C17H19FN4O2
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