AKT (phospho Thr308) antibody-多抗-深圳欣博盛生物科技有限公司

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AKT (phospho Thr308) antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX28933

规格：100μg

目录价：￥9100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

AKT (phospho Thr308) antibody

别名:

AKT serine/threonine kinase 1 , AKT , CWS6 , PKB , PKB-ALPHA , PRKBA , RAC , RAC-ALPHA

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

Dot, ELISA, FCM, IHC-P, WB

靶标/特异性:

This antibody is specific for phosphorylated human AKT. Minimal reactivity occurs against non-phosphorylated AKT.

同种型:

IgG

免疫原:

A phosphorylated synthetic peptide corresponding to residues surrounding threonine 308 of human AKT1 protein.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

Akt (Protein Kinase B, PKB) is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. Akt mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits Akt to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, Akt dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. Akt has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.

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