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折扣/货期| 货号：GTX642060 | 规格：100μl | 目录价：￥4000 |
| 货号：GTX642060-S | 规格：25μl | 目录价：￥1700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
alpha Actinin 4 antibody [GT95]
别名:
actinin alpha 4 , ACTININ-4 , FSGS , FSGS1
反应种属:
Human
宿主来源:
Mouse
实验应用:
WB
靶标/特异性:
This antibody is specific for human alpha Actinin 4 protein and does not cross react with human alpha Actinin 1, alpha Actinin 2, and alpha Actinin 3 protein.
同种型:
IgG1
免疫原:
Recombinant fragment of human alpha Actinin 4.
克隆性:
Monoclonal
克隆号:
GT95
纯化方式:
Affinity purified by Protein A.
偶联:
Unconjugated
产品浓度:
1 mg/ml
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
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