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折扣/货期| 货号：GTX57544 | 规格：100μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
alpha B Crystallin antibody [2E8]
别名:
crystallin alpha B , CMD1II , CRYA2 , CRYAB , CTPP2 , CTRCT16 , HELS101 , HSPB5 , MFM2 , alpha B Crystallin
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ICC/IF, WB
靶标/特异性:
The clone 2E8 is specific for crystallin alpha B, but does not cross crystallin alpha A.
同种型:
IgG2b
免疫原:
The clone 2E8 is derived from hybridization of mouse SP4/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant Human Crystallin alpha B.
克隆性:
Monoclonal
克隆号:
200000000
纯化方式:
Protein G Purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 10% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
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