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折扣/货期| 货号：GTX13497 | 规格：100μl | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
alpha B Crystallin antibody
别名:
crystallin alpha B , CMD1II , CRYA2 , CTPP2 , CTRCT16 , HEL-S-101 , HSPB5 , MFM2
反应种属:
Bovine, Hamster, Human, Mouse, Pig, Rabbit, Rat
宿主来源:
Rabbit
实验应用:
ICC/IF, IHC, IP, WB
靶标/特异性:
This antibody does not cross-react with beta Crystallin nor alpha A Crystallin.
同种型:
IgG
免疫原:
Synthetic peptide: REEKPAVTAAPKK conjugated to KLH, corresponding to amino acids 163-175 of Human alpha B Crystallin.
克隆性:
Polyclonal
克隆号:
纯化方式:
Protein A affinity purified.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
20
产品形式:
Liquid
存储溶液:
PBS, 50% Glycerol, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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