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折扣/货期| 货号：AG-25T-0116-C025 | 规格：25 ug | 目录价：￥14400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-Collagen Type 1 (3/4 fragment), pAb
别名:
COL1; alpha-1 Type I Collagen
产品描述:
The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic ¾ and ¼ fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen ¾ fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure.
宿主来源:
Rabbit
实验应用:
ICC, WB
靶标/特异性:
Recognizes rat and bovine collagen type 1. Based on sequence identity should also recognize human, mouse, guinea pig, dog, cat, donkey, pig, cow, sheep and chicken collagen type 1.
免疫原:
Synthetic peptide (human sequence) corresponding to the C-terminal end of the N-terminal three quarter collagen fragment (Col1 ¾).
产品浓度:
250µg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.
产地:
瑞士
纯度:
Antigen affinity purified.
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