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折扣/货期| 货号：AG-25T-0117-C010 | 规格：10 ug | 目录价：￥5040 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-Profilin, pAb (IG-706)
别名:
PFN1
产品描述:
Profilin (PFN1) is a ubiquitous small (12-15kDa) phosphoinositide and poly-L-proline binding protein that plays a role in signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties. Whereas profilin I appears to be highly expressed in most tissues except for skeletal muscle, profilin II is predominantly expressed in brain and at lower levels also in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes. Profilin binding to PIP2 interferes with PIP2 hydrolysis by soluble phospholipase C-gamma, an inhibition that can be overcome by tyrosine phosphorylation of PLC-gamma. Besides actin monomer sequestration and stimulation of actin nucleotide exchange, profilin can also promote cellular actin filament growth. Profilin is involved in the actin dependent intracellular motility of cytopathogenic bacteria, the regulation of cell adhesion and possibly also in linking the actin cytoskeleton and endocytosis. Profilin has been found to associate with defined complexes containing proteins such as Arp2/3 or the Rho/Rac pathways constituents ROCK-II and HEM2/NAP1. Defects in PFN1 are the cause of amyotrophic lateral sclerosis 18 (ALS18).
宿主来源:
Rabbit
实验应用:
ICC, IHC, WB
靶标/特异性:
Recognizes human, mouse, rat, pig, bovine and marsupial profilin.
免疫原:
Human full-length profilin.
产品浓度:
100µg/ml
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
产地:
瑞士
纯度:
Antigen affinity purified.
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