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折扣/货期| 货号：REV-31-1364-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-FAK (Focal adhesion kinase 1), Rabbit Monoclonal (RM472)
别名:
Focal Adhesion Kinase 1; Protein-tyrosine Kinase 2; PTK2
产品描述:
FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-kappaB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-kappaB pathway is involved in the regulation of inflammation and immunity.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
RM472 reacts to human FAK (Focal adhesion kinase 1). This antibody may also react to mouse or rat FAK, as predicted by immunogen homology.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to residues surrounding Tyr397 of human FAK1 (Focal adhesion kinase 1).
克隆号:
RM472
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
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