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折扣/货期| 货号：REV-31-1394-00-R100 | 规格：100 ul | 目录价：￥5558 |
产品详情
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产品名称:
anti-FGL1 (human), Rabbit Monoclonal (RM502)
别名:
Fibrinogen-like Protein 1; FGL-1; Hepatocyte-derived Fibrinogen-related Protein 1; HFREP-1; Hepassocin
产品描述:
FGL1 (Fibrinogen-like protein 1, also called Hepatocyte-derived fibrinogen-related protein 1, HFREP-1 or Hepassocin) was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. A low level expression of FGL1 is also observed in the pancreas. FGL1 is a 34kDa protein structurally similar to Angiopoietin-like factors 2, 3, 4 and 6, which regulate lipid metabolism and energy utilization. It was proposed that FGL1 is a member of an emerging group of proteins having potential roles in liver metabolism and liver regeneration. Recently, FGL1 has also been shown to be upregulated in human cancers and FGL1 is a major functional ligand of LAG-3. FGL1 interacts with LAG-3 in a MHC-II-independent manner and this interaction involves the FGL1 fibrinogen-like domain and the LAG-3 D1-D2 domain. FGL1-LAG-3 interaction blockade promotes tumor immunity by stimulating T cell expansion and activation. FGL1 forms two disulfide-linked homodimers and also higher molecular weight homooligomers that bind to LAG-3 much better than the dimeric forms. This binding to LAG-3 inhibits T cell responses. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/ B7-H1 therapy.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
This antibody reacts to human FGL1.
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to the C-terminus of human FGL1.
克隆号:
RM502
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
纯度:
Protein A purified.
促销活动
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