anti-GATA3, Rabbit Monoclonal (RM482)-单抗-深圳欣博盛生物科技有限公司

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anti-GATA3, Rabbit Monoclonal (RM482)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1374-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-GATA3, Rabbit Monoclonal (RM482)

别名:

Trans-acting T-cell-specific Transcription Factor GATA-3; GATA-Binding Factor 3

产品描述:

GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. GATA3 coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL-33. Upon tissue injury, acts downstream of IL-33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome).

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human GATA3 and may also react to mouse or rat GATA3, as predicted by immunogen homology.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to human GATA3.

克隆号:

RM482