anti-Lewis y/b hapten (human), mAb (SC104) (preservative free)-单抗-深圳欣博盛生物科技有限公司

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anti-Lewis y/b hapten (human), mAb (SC104) (preservative free)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-6002PF-C100

规格：100 ug

目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Lewis y/b hapten (human), mAb (SC104) (preservative free)

别名:

CD174; Sialyltetraosylceramide; NCRC37

产品描述:

Membrane glycolipids represent an unexplored source of tumor-associated antigens. Many of these are overexpressed and altered in tumors compared to normal tissue. Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, has provided a novel area of targets for cancer immunotherapy. Lewis-y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be overexpressed on breast, lung, colon and ovarian cancer cells. Clone SC104 recognizes a unique cell surface antigen sialyltetraosylceramide, expressed by 90% of colorectal tumors at all clinical stages. SC104 targets colorectal cancer-associated glycolipids and induces tumor cell death in vitro independently of CDC or ADCC or blockade of known survival signaling pathways. It induces apoptotic cell death and synergizes with chemotherapy in vivo in mice.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, FACS, FUNC (Blocking), ICC, IHC

靶标/特异性:

Recognizes human sialyltetraosylceramide. Does not bind to blood lympocytes, granulocytes, bone marrow progenitor cells, GM1, GD1a, GT1b or sialyl LewisX antigens.

同种型:

Mouse IgG1

免疫原:

Tissue cultured colorectal tumor cell lines (C170, C146, Colo205 and JW).

克隆号:

SC104

产品浓度:

Lot dependent

保存温度:

+4°C

运输温度:

BI (not freeze)