anti-GBP1 (human), pAb (IN111)-多抗-深圳欣博盛生物科技有限公司

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anti-GBP1 (human), pAb (IN111)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-25B-6001-C050

规格：50 ug

目录价：￥1920

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-GBP1 (human), pAb (IN111)

别名:

Guanylate-binding Protein 1; GTP-binding Protein 1; Guanine Nucleotide-binding Protein 1; Interferon-induced Guanylate-binding Protein 1

产品描述:

Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.

宿主来源:

Rabbit

实验应用:

靶标/特异性:

Recognizes endogenous human GBP1.

免疫原:

Recombinant human GBP1 protein (aa 200-592).

产品浓度:

1mg/ml

保存温度:

+4°C

运输温度: