anti-Phospho-Stat3 (Tyr705) (human), Rabbit Monoclonal (RM261)-单抗-深圳欣博盛生物科技有限公司

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anti-Phospho-Stat3 (Tyr705) (human), Rabbit Monoclonal (RM261)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1142-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Phospho-Stat3 (Tyr705) (human), Rabbit Monoclonal (RM261)

别名:

Signal Transducer and Activator of Transcription 3; Acute-phase Response Factor

产品描述:

STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation and DNA binding activity. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage. STAT3 is essential for the differentiation of the TH17 helper T cells, which have been implicated in a variety of autoimmune diseases. STAT3 can promote oncogenesis by being constitutively active through various pathways and increased activity of STAT3 in cancer cells, leads to changes in the function of protein complexes that control expression of inflammatory genes.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to human Stat3 only when phosphorylated at Tyr705. There is no cross-reactivity to stat3 without phosphorylation at Tyr705. This antibody may also react to mouse or rat Phospho-Stat3 (Tyr705), as predicted by immunogen homology.

同种型:

Rabbit IgG

免疫原:

A phospho-peptide corresponding to human Phospho- Stat3 (Tyr705).

克隆号:

RM261

产品浓度:

N/A

保存温度:

+4°C

运输温度:

产品形式: