BIoXCell新品推荐:InVivoSIM anti-human TROP-2(Sacituzumab Biosimilar)
InVivoSIM anti-human TROP-2 (Sacituzumab Biosimilar) clone: Sacituzumab (Catalog #SIM0051)
产品中文名称:InVivoSIM 抗人TROP-2(Sacituzumab 生物仿制药)抗体,克隆:Sacituzumab(目录号 #SIM0051)
(产品示例图)
Key features:
▲ Sacituzumab is a humanized IgG1κ against human trophoblastic cell surface antigen 2 (TROP-2).
▲ TROP-2 is a cell surface receptor, and its ligands include claudin-1, claudin-7, cyclin D1, and IGF-1.
▲ TROP2 is an upcoming tumor antigen that is expressed in glioblastoma, pancreatic carcinoma, and all breast cancer subtypes. TROP-2 is a cellular marker of trophoblastic stem cells.
▲ TROP2 transduces calcium signals and drives tumor proliferation, invasion, and metastasis.
▲ The tumor cell-specific expression of TROP-2 makes it an ideal target for cancer immunotherapy.
▲ Sacituzumab is used for making antibodydrug conjugates (ADC) and also to eradicate cancer cells.
Application: in vitro functional assays, in vivo functional assays, Antibody-drug conjugate synthesis, ELISA, Western blot, Flow cytometry
cytometry Research Area: Tumor Antigens, Cancer Biology
Related targets: EGFR, EPCAM (CD326), HER2/erbB2, PSMA, EphA2, CEACAM
主要特点:
▲ Sacituzumab 是一种针对人滋养细胞表 面抗原 2(TROP-2)的重组人源化 IgG1κ 抗体。
▲ TROP-2 是一种细胞表面受体,其配体 包括 claudin-1、claudin-7、cyclin D1 和 IGF-1。
▲ TROP-2 是新兴的肿瘤抗原,表达于胶 质母细胞瘤、胰腺癌以及所有乳腺癌亚 型中。TROP-2 是滋养细胞干细胞的细 胞标志物。
▲ TROP-2 传导钙信号,并驱动肿瘤的增 殖、侵袭和转移。
▲ TROP-2 在肿瘤细胞中的特异性表达使 其成为癌症免疫疗法的理想靶点。
▲ Sacituzumab 用于抗体药物偶联物 (ADC)的合成,同时也用于消除癌细 胞。
应用:体外功能实验、体内功能实验、抗体药物偶 联物合成、ELISA、Western blot、流式细胞术
研究领域:肿瘤抗原、癌症生物学
相关靶点:EGFR、EPCAM(CD326)、HER2/erbB2、 PSMA、EphA2、CEACAM
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