TLR2激动剂(又名CD282)及相关产品介绍-深圳欣博盛生物科技有限公司

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TLR2激动剂(又名CD282)及相关产品介绍

发布日期：2024-10-24

编辑：市场部

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TLR2(又名CD282)是一个可以识别多种微生物表面分子的细胞膜表面受体。它识别的分子可来源于革兰氏阳性菌、革兰氏阴性菌、支原体和酵母等许多微生物种属。

TLR2识别的具体成份包括来源于革兰氏阳性菌的肽聚糖、脂膜酸、脂蛋白，来源于分枝杆菌的脂阿拉伯甘露聚糖，来源于酵母细胞壁的酵母聚糖等。

TLR2识别的配体种类在TLR家族中是最多的，因为TLR2可以和其它TLR家族成员形成异源二聚体来发挥功能。

TLR2可以和TLR6形成异源二聚体识别双酰化脂蛋白，而TLR1/TLR2异源二聚体则与三酰化脂蛋白发生相互作用。

另外，CD14共受体的存在可增强TLR2的病原识别能力。TLR2信号通路的激活依赖于MyD88分子(骨髓来源的第一应激蛋白88)，进而招募接头分子TIRAP(TIR相关蛋白)，导致AP-1和NF-kB等转录因子入核来促进一些炎症因子的释放。

TLR2激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR LIGANDS
TLR2 Agonists
CL401	PAM2C-conjugated hydroxyadenine compound	TLR2 +/ TLR4 -	1 ng - 10 µg/ml	500 µg	tlrl-c401
CL401 VacciGrade™	Preclinical grade CL401	VacciGrade™	20 - 50 µg/mouse	5 mg	vac-c401-5
CL413 - Adilipoline™	PAM2CK4-conjugated hydroxyadenine compound	TLR2 +/ TLR4 -	50 pg - 10 µg/ml	500 µg	tlrl-c413
CL413 VacciGrade™	Preclinical grade CL413	VacciGrade™	20 - 50 µg/mouse	5 mg	vac-c413-5
CL419	Pam2C-spermine compound	TLR2 +/ TLR4 -	1 ng - 100 µg/ml	500 µg	tlrl-c419
CL429	Pam2C-conjugated murabutide	TLR2 +/ TLR4 -	1 ng - 10 µg/ml	5 mg	tlrl-c429
CL429 VacciGrade™	Preclinical grade CL429	VacciGrade™	20 - 50 µg/mouse	5 mg	vac-c429
CL531	PAM2CK4-conjugated hydroxyadenine compound	TLR2 +/ TLR4 -	5 pg - 10 µg/ml	500 µg	tlrl-c531
CL572	Monoacyl-ethyl-cystein hydroxyadenine compound	TLR2 +/ TLR4 -	0.5 ng - 1 µg/ml	500 µg	tlrl-c572
FSL-1	Synthetic diacylated lipoprotein - TLR2/6	TLR2 +/ TLR4 -	1 - 100 ng/ml	100 µg	tlrl-fsl
HKBF	Heat Killed Bacteroides fragilis	TLR2 +/ TLR4 -	106 - 107 cells/m	109 cells	tlrl-hkbf
HKEB	Heat Killed Escherichia coli 0111:B4	TLR2 +/ TLR4 +	105 - 107 cells/ml	1010 cells	tlrl-hkeb
HKLM	Heat Killed Listeria monocytogenes	TLR2 +/ TLR4 -	107 - 108 cells/ml	1010 cells	tlrl-hklm
HKLR	Heat Killed Lactobacillus rhamnosus	TLR2 +/ TLR4 -	108 - 109 cells/ml	1010 cells	tlrl-hklr
HKMT	Heat Killed Mycobacterium tuberculosis	TLR2 +/ TLR4 -	100 ng - 10 µg/ml	10 mg 50 mg	tlrl-hkmt-1 tlrl-hkmt-5
HKPA	Heat Killed Pseudomonas aeruginosa	TLR2 +/ TLR4 -	105 - 107 cells/ml	1010 cells	tlrl-hkpa
HKSA	Heat Killed Staphylococcus aureus	TLR2 +/ TLR4 -	106 - 108 cells/ml	1010 cells	tlrl-hksa
HKSE	Heat Killed Staphylococcus epidermidis	TLR2 +/ TLR4 -	107 - 109 cells/ml	1010 cells	tlrl-hkse
HKSP	Heat Killed Streptococcus pneumoniae	TLR2 +/ TLR4 -	107 - 109 cells/ml	1010 cells	tlrl-hksp
HKST	Heat Killed Salmonella typhimurium	TLR2 +/ TLR4 +	104 - 109 cells/ml	1010 cells	tlrl-hkst
LPS-PG	Standard Lipopolysaccharide from P. gingivalis	TLR2 +/ TLR4 +	10 ng - 10 mg/ml	1 mg	tlrl-pglps
LTA-BS	Lipoteichoic acid from Bacillus subtilis	TLR2 +/ TLR4 +	100 ng - 1 µg/ml	5 mg	tlrl-lta
LTA-SA	Lipoteichoic acid from S. aureus	TLR2 +/ TLR4 +	100 ng - 1 µg/ml	5 mg	tlrl-slta
LTA-SA Purified	Purified lipoteichoic acid from S. aureus	TLR2 +/ TLR4 -	1 ng - 1 µg/ml	5 mg	tlrl-pslta
Pam2CSK4	Synthetic diacylated lipoprotein - TLR2(6)	TLR2 +/ TLR4 -	1 - 100 ng/ml	1 mg	tlrl-pm2s-1
Pam3CSK4	Synthetic triacylated lipoprotein - TLR1/2	TLR2 +/ TLR4 -	1 - 300 ng/ml	1 mg	tlrl-pms
Pam3CSK4 Biotin	Biotinylated Pam3CSK4	TLR2 +/ TLR4 -	10 - 300 ng/ml	50 µg	tlrl-bpms
Pam3CSK4 Rhodamine	Rhodamine-labeled Pam3CSK4	TLR2 +/ TLR4 -	1 - 300 ng/ml	50 µg	tlrl-rpms
Pam3CSK4 VacciGrade™	Preclinical grade Pam3CSK4	VacciGrade™	2 - 20 µg/mouse	1 mg	vac-pms
PGN-BS	Peptidoglycan from B. subtilis	TLR2 +/ TLR4 -	1 - 10 µg/ml	5 mg	tlrl-pgnb3
PGN-EB	Peptidoglycan from E. coli 0111:B4	TLR2 +/ TLR4 +	1 - 10 µg/ml	1 mg	tlrl-pgneb
PGN-EK	Peptidoglycan from E. coli K12	TLR2 +/ TLR4 +	1 - 10 µg/ml	1 mg	tlrl-pgnek
PGN-SA	Peptidoglycan from S. aureus	TLR2 +/ TLR4 -	0.1 - 10 µg/ml	5 mg	tlrl-pgns2
Zymosan	Cell wall preparation of S. cerevisiae	TLR2 +/ TLR4 -	1-10 µg/ml	100 mg	tlrl-zyn