sting激动剂及相关产品推荐-深圳欣博盛生物科技有限公司

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sting激动剂及相关产品推荐

发布日期：2024-10-24

编辑：市场部

浏览次数：35

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STING分子在最初发现时只被认为是CDS信号通路中的一个普通接头蛋白，进一步研究表明它是环二核苷酸cyclic dinucleotide(CDNs)的直接感受分子。CDNs是细菌合成的重要第二信使，调节原核生物及哺乳动物的众多生物进程，能启动宿主天然免疫反应。CDNs和山酮衍生物xanthenone derivative(例如DMXAA)，可结合并活化STING，通过TBK1-IRF3依赖的信号通路来诱导I型干扰素表达。

相关产品推荐：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
STING Agonists
2’2’-cGAMP	2’5’-2’5’ Cyclic GMP-AMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	500 µg 1 mg	tlrl-nacga22 tlrl-nacga22-1
2’3’-cGAMP	2’5’-3’5’ Cyclic GMP-AMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	200 µg 500 µg 1 mg 5 mg	tlrl-ncga23-02 tlrl-nacga23 tlrl-nacga23-1 tlrl-nacga23-5
2’3’-cGAMP Control	Linear dinucleotide analog of 2’3’-cGAMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	1 mg	tlrl-nagpap
2’3’-cGAMP VacciGrade™	Preclinical grade 2’5’-3’5’ cyclic GMP-AMP	VacciGrade™	5 - 50 µg/mouse	1 mg	vac-nacga23
2’3’-cGAM(PS)2 (Rp/Sp)	Bis-phosphorothioate analog of 2’3’-cGAMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	250 µg	tlrl-nacga2srs
2’3’-c-di-AMP	Synthetic analog of c-di-AMP	TLR2 -/ TLR4 -	1 - 100 µg/ml	500 µg	tlrl-nacda23
2’3’-c-di-AM(PS)2 (Rp,Rp)	Bisphosphorothioate analog of 2’3’-c-di-AMP	TLR2 -/ TLR4 -	0.1-10 µg/ml	100 µg 500 µg	tlrl-nada2r-01 tlrl-nacda2r
2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade™	Preclinical grade of bisphosphorothioate analog of 2’3’-c-di-AMP	VacciGrade™	5-50 µg/mouse	500 µg	vac-nacda2r
2’3’-c-di-GMP	Synthetic analog of c-di-GMP	TLR2 -/ TLR4 -	1 - 100 µg/ml	500 µg	tlrl-nacdg23
3’3’-cGAMP	3’5’-3’5’ Cyclic GMP-AMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	500 µg 1 mg 5 x 0.5 mg	tlrl-nacga tlrl-nacga-1 tlrl-nacga-2.5
3’3’-cGAMP Control	Linear dinucleotide analog of 3’3’-cGAMP	TLR2 -/ TLR4 -	100 ng - 100 µg/ml	1 mg	tlrl-nagpap
3’3’-cGAMP Fluorinated	Difluor cyclic [G(3’,5’)pA(3’,5’)p]	TLR2 -/ TLR4 -	100 ng - 10 µg/ml	100 µg	tlrl-nacgaf
cAIMP (CL592)	Cyclic [A(3’,5’)pI(3’,5’)p]	TLR2 -/ TLR4 -	300 ng - 30 µg/ml	500 µg	tlrl-nacai
cAIMP Difluor (CL614)	Difluor cyclic [A(3’,5’)pI(3’,5’)p]	TLR2 -/ TLR4 -	100 ng - 30 µg/ml	250 µg	tlrl-nacaidf
cAIM(PS)2 Difluor (Rp/Sp)	Difluor and bisphosphorothioate analog of cAIMP	TLR2 -/ TLR4 -	100 ng - 30 µg/ml	100 µg	tlrl-nacairs
c-di-AMP	3’5’ Cyclic di-AMP	TLR2 -/ TLR4 -	1 - 100 µg/ml	1 mg 5 x 1 mg	tlrl-nacda tlrl-nacda-5
c-di-AMP Control	Linear dinucleotide analog of c-di-AMP - pApA	TLR2 -/ TLR4 -	1 - 100 µg/ml	1 mg	tlrl-napapa
c-di-AMP VacciGrade™	Sterile 3’5’ cyclic di-AMP	VacciGrade™	5 - 50 µg/mouse	1 mg	vac-nacda
c-di-AMP Fluorinated	Difluoro [A(3’,5’)pA(3’,5’)p]	TLR2 -/ TLR4 -	300 ng - 30 µg/ml	100 µg	tlrl-nacdaf
c-di-GMP	3’5’ Cyclic di-GMP	TLR2 -/ TLR4 -	10 - 100 µg/ml	1 mg 5 x 1 mg	tlrl-nacdg tlrl-nacdg-5
c-di-GMP Control	Linear dinucleotide 5’-pGpG; negative control for c-di-GMP	TLR2 -/ TLR4 -	10 - 100 µg/ml	1 mg	tlrl-napgpg
c-di-GMP VacciGrade™	Preclinical grade of cyclic [G(3’,5’)pG(3’,5’)p]	VacciGrade™	5 - 50 µg/mouse	1 mg	tlrl-nacdg
c-di-GMP Fluorinated	Difluoro cyclic [G(3’,5’)pG(3’,5’)p]	TLR2 -/ TLR4 -	3 - 100 µg/ml	100 µg	tlrl-nacdgf
c-di-IMP	Cyclic [I(3’,5’)pI(3’,5’)p]	TLR2 -/ TLR4 -	10 - 100 µg/ml	1 mg	tlrl-nacdi
c-di-UMP	Negative control for c-di-IMP	TLR2 -/ TLR4 -	1 - 100 µg/ml	1 mg	tlrl-nacdu
DMXAA	5,6-dimethyl-xanthenone-4-acetic acid	TLR2 -/ TLR4 -	10 - 100 µg/ml	5 mg	tlrl-dmx