ODN 2006——人TLR9激动剂
![](https://connect.qq.com/widget/shareqq/index.html?url=http%3A%2F%2Fwww.nbs-bio.com%2Farticle%2F766.html&title=ODN%202006%E2%80%94%E2%80%94%E4%BA%BATLR9%E6%BF%80%E5%8A%A8%E5%89%82-%E6%B7%B1%E5%9C%B3%E6%AC%A3%E5%8D%9A%E7%9B%9B%E7%94%9F%E7%89%A9%E7%A7%91%E6%8A%80%E6%9C%89%E9%99%90%E5%85%AC%E5%8F%B8&source=ODN%202006%E2%80%94%E2%80%94%E4%BA%BATLR9%E6%BF%80%E5%8A%A8%E5%89%82-%E6%B7%B1%E5%9C%B3%E6%AC%A3%E5%8D%9A%E7%9B%9B%E7%94%9F%E7%89%A9%E7%A7%91%E6%8A%80%E6%9C%89%E9%99%90%E5%85%AC%E5%8F%B8&desc=TLR9%E8%AF%86%E5%88%AB%E7%89%B9%E5%AE%9A%E7%9A%84%E6%9C%AA%E7%94%B2%E5%9F%BA%E5%8C%96%E7%9A%84CpG-ODN%E5%BA%8F%E5%88%97%EF%BC%8C%E5%85%B6%E5%8F%AA%E5%AD%98%E5%9C%A8%E4%BA%8E%E5%BE%AE%E7%94%9F%E7%89%A9DNA%E8%80%8C%E4%B8%8D%E5%AD%98%E5%9C%A8%E4%B8%8E%E5%93%BA%E4%B9%B3%E5%8A%A8%E7%89%A9%E7%9A%84DNA%E3%80%82InvivoGen%E5%8F%AF%E6%8F%90%E4%BE%9B%E4%B8%89%E7%A7%8D%E7%B1%BB%E5%9E%8B%E7%9A%84%E5%88%BA%E6%BF%80%E5%9E%8BODNs%EF%BC%9AA%E6%80%A7%E3%80%81B%E5%9E%8B%E5%92%8CC%E5%9E%8B%EF%BC%8C%E4%B9%9F%E5%8F%AF%E6%8F%90%E4%BE%9B%E5%AF%B9%E7%85%A7ODNs%E5%92%8C%E6%8A%91%E5%88%B6%E5%9E%8BODNs%E3%80%82&pics=http%3A%2F%2Fwww.nbs-bio.com%2Fupload%2Fimages%2Fsite%2F20240816%2F17237797827890045.png&summary="TLR9%E8%AF%86%E5%88%AB%E7%89%B9%E5%AE%9A%E7%9A%84%E6%9C%AA%E7%94%B2%E5%9F%BA%E5%8C%96%E7%9A%84CpG-ODN%E5%BA%8F%E5%88%97%EF%BC%8C%E5%85%B6%E5%8F%AA%E5%AD%98%E5%9C%A8%E4%BA%8E%E5%BE%AE%E7%94%9F%E7%89%A9DNA%E8%80%8C%E4%B8%8D%E5%AD%98%E5%9C%A8%E4%B8%8E%E5%93%BA%E4%B9%B3%E5%8A%A8%E7%89%A9%E7%9A%84DNA%E3%80%82InvivoGen%E5%8F%AF%E6%8F%90%E4%BE%9B%E4%B8%89%E7%A7%8D%E7%B1%BB%E5%9E%8B%E7%9A%84%E5%88%BA%E6%BF%80%E5%9E%8BODNs%EF%BC%9AA%E6%80%A7%E3%80%81B%E5%9E%8B%E5%92%8CC%E5%9E%8B%EF%BC%8C%E4%B9%9F%E5%8F%AF%E6%8F%90%E4%BE%9B%E5%AF%B9%E7%85%A7ODNs%E5%92%8C%E6%8A%91%E5%88%B6%E5%9E%8BODNs%E3%80%82")
TLR9识别特定的未甲基化的CpG-ODN序列，其只存在于微生物DNA而不存在与哺乳动物的DNA。InvivoGen可提供三种类型的刺激型ODNs：A性、B型和C型，也可提供对照ODNs和抑制型ODNs。
CpG ODNs是一种合成的寡核苷酸，在CpG motifs序列处含有非甲基化的CpG二核苷酸，这些CpG motifs在细菌DNA出现的频率为哺乳动物DNA的20倍。CpG ODNs可被toll样受体9识别，诱导很强的免疫刺激效应。
ODN 2006属于B型CpG ODNs，为人TLR9的配体。 B型CpG ODNs包含一个完整的硫代磷酸酯主体和一个或多个CpG二核苷酸。可强有效的活化B细胞但是弱刺激IFN-α的分泌。
ODN 2006 Vaccigrade™适用于临床前研究，在严格的无菌条件下制备，确保无菌，并且内毒素含量非常低。
产品名称 | 产品描述 | 规格 | 货号 |
TLR9 Agonist - Stimulatory CpG ODN, Class B, Human specific | 200ug | tlrl-2006 | |
1mg | tlrl-2006-1 | ||
5mg | tlrl-2006-5 | ||
TLR9 agonist - CpG ODN, class B (human) Th1 response | 1mg | vac-2006-1 | |
ODN 2137 : Negative control for ODN 2006 | 200ug | tlrl-2006c | |
1mg | tlrl-2006c-1 | ||
5mg | tlrl-2006c-5 | ||
TLR9 Agonist - Biotin-labelled CpG ODN 2006, Class B, Human specific | 50ug | tlrl-2006b | |
TLR9 Agonist - FITC-labelled CpG ODN 2006, Class B, Human specific | 50ug | tlrl-2006f | |
TLR9 Agonist - Stimulatory CpG ODN, Class B, Human specific | 200ug | tlrl-2006g5 | |
Negative control for ODN 2006-G5 | 1mg | tlrl-2006g5-1 | |
5mg | tlrl-2006g5-5 | ||
200ug | tlrl-2006g5c |
