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折扣/货期| 货号：GTX00686 | 规格：100μg | 目录价：￥6500 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ATF6 antibody [37-1]
别名:
activating transcription factor 6 , ACHM7 , ATF6A
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
IP, WB
靶标/特异性:
This antibody detects both full-length ATF6 alpha as well as the cleaved ATF6 alpha p50 form.This antibody is less efficient for IP compared to GTX00687
同种型:
IgG1
免疫原:
Recombinant ATF6 alpha; (amino-terminal fragment of ATF6 alpha; fused to GST)
克隆性:
Monoclonal
克隆号:
37-1
纯化方式:
Purified IgG
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Filter-sterilized PBS, 50% Glycerol, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
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