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折扣/货期| 货号：95-122 | 规格：0.05 mg | 目录价：￥4226.625 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ATG7 Recombinant Protein
别名:
ATG7 Recombinant Protein: Agp7, Apg7l, Atg7l, Gm21553, 1810013K23Rik
实验应用:
ELISA,WB
表达系统:
E. coli
保存温度:
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
1X PBS containing 10% glycerol
产地:
美国
生产商:
Prosci
功能与背景:
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).
纯度:
~95%
Accession #:
AAH58597
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