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折扣/货期| 货号：RF16000-01 | 规格：0.1 mg | 目录价：￥9477 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PD1 Recombinant Protein
别名:
PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l, PD-1
实验应用:
WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
纯度:
>95% as determined by SDS-PAGE.
生物活性:
(1) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, His Tag at 2 ug/mL (100 uL/well) can bind Human PD-L1, Fc Tag with a linear range of 0.8-250 ng/mL. (2) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, His Tag at 0.2 ug/mL (100 ul/well) can bind Human PD-L2, Fc Tag with a linear range of 0.16-2.5 ug/mL.
Accession #:
NP_005009.2
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