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折扣/货期| 货号：RF16010-01 | 规格：0.1 mg | 目录价：￥5756.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CTLA 4 Recombinant Protein
别名:
CTLA4, CD152, CELIAC3, GRD4, GSE, ICOS, IDDM12
实验应用:
WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
纯度:
>95% as determined by SDS-PAGE.
生物活性:
Measured by its binding ability in a functional ELISA. Immobilized Human CTLA4 Protein at 2μg/mL (100μL/well) can bind rhB7-1/ CD80 Protein Fc Chimera with a linear range of 2 - 50 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Human CTLA4 Protein at 10μg/mL (100μL/well) can bind rh PD-L1 /B7-H1 /CD274 Protein Fc Chimera with a linear range of 20 - 10000 ng/mL.
Accession #:
NP_005205.2
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