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折扣/货期| 货号：GTX70103 | 规格：100μl | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ATM antibody [2C1]
别名:
ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1
产品描述:
ATM antibody [2C1] is a mouse monoclonal antibody developed by Dr. Eva Lee’s lab at the University of Texas Health Science Center at San Antonio (PMID: 8969240). It is a well-validated and highly cited reagent to detect ATM protein, which is a nuclear serine/threonine kinase that plays a pivotal role in DNA damage sensing and repair.
反应种属:
Human, Monkey, Mouse, Rat
宿主来源:
Mouse
实验应用:
ChIP assay, ELISA, FCM, ICC/IF, IHC, IHC-P, IP, WB
同种型:
IgG1
免疫原:
Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
克隆性:
Monoclonal
克隆号:
2C1
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
0.99 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
351
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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