ATXN2 antibody [HL1903]-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

ATXN2 antibody [HL1903]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX637652	规格：100μl	目录价：￥4000
货号：GTX637652-S	规格：25μl	目录价：￥1700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ATXN2 antibody [HL1903]

别名:

ataxin 2 , ATX2 , SCA2 , TNRC13

反应种属:

Human

宿主来源:

Rabbit

实验应用:

同种型:

IgG

免疫原:

Recombinant fragment of human ATXN2

克隆性:

Monoclonal

克隆号:

HL1903

纯化方式:

Affinity purified by Protein A.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

您可能感兴趣的产品

Alpha Synuclein Oligomer Antibody

货号：SMC-622S

Alpha Synuclein Oligomer Antibody: RPE

货号：SMC-622D-RPE

Alpha Synuclein Oligomer Antibody: PerCP

货号：SMC-622D-PCP

Alpha Synuclein Oligomer Antibody: HRP

货号：SMC-622D-HRP

Alpha Synuclein Oligomer Antibody: FITC

货号：SMC-622D-FITC

Alpha Synuclein Oligomer Antibody: Biotin