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折扣/货期| 货号：AG-CR1-3692-M001 | 规格：1 mg | 目录价：￥420 |
| 货号：AG-CR1-3692-M005 | 规格：5 mg | 目录价：￥1560 |
| 货号：AG-CR1-3692-M010 | 规格：10 mg | 目录价：￥2880 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AZD 7545
别名:
4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-benzamide
产品描述:
Potent and selective pyruvate dehydrogenase kinase 2 (PDK2) inhibitor (IC50=6.4nM), consequently increasing pyruvate dehydrogenase (PDH) activity. Less potent inhibitor towards PDK1 and PDK3 (IC50=87 and 600nM, respectively). Inhibitor of glycolysis. Antiobesity and antidiabetic agent. Improves blood glucose control in obese (fa/fa) Zucker rats. Useful agent for immunometabolism research. To maintain a continuous and steady supply of ATP during the feed-fast cycle, cells must select fatty acid or glucose for fuel. This process is largely controlled by the pyruvate dehydrogenase complex (PDC), which regulates the entry of glycolytic products into the tricarboxylic acid cycle by catalyzing the oxidative decarboxylation of pyruvate to acetyl-coenzyme A (CoA) in the mitochondria of mammalian cells. PDKs and pyruvate dehydrogenase phosphatases (PDPs) are key regulators of PDC activity, and they act in a phosphorylation-dephosphorylation manner.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
478.9
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
252017-04-2
分子式:
C19H18ClF3N2O5S
溶解度:
Soluble in DMSO (40mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
促销活动
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