STF-31-抑制剂-深圳欣博盛生物科技有限公司

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STF-31

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3693-M001	规格：1 mg	目录价：￥480
货号：AG-CR1-3693-M005	规格：5 mg	目录价：￥1140
货号：AG-CR1-3693-M025	规格：25 mg	目录价：￥3480

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

STF-31

别名:

4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide

产品描述:

Specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor (IC50=19nM), consequently blocking the NAD+ salvage pathway and leading to blockage of GLUT1 expression. Glucose transporter 1 (GLUT1) inhibitor (IC50 ~1µM). Inhibits glucose uptake across the plasma membranes of mammalian cells and consequently decreases glycolysis. Anticancer agent. Shown to induce necrosis in cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor gene, which overexpresses GLUT1. VHL-deficient cancer cells are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. Completely suppresses the glucose uptake activity and induces apoptosis in GLUT1 expressing myeloma cells as well. Useful agent for immunometabolism research. Toxic to human pluripotent stem cells (hPSCs) and used to selectively eliminate hPSCs from mixed cultures.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

423.5

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)