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折扣/货期| 货号：CHI-MF-110B7H4-C100 | 规格：100 ug | 目录价：￥5040 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
B7-H4 (mouse):Fc (mouse) (rec.)
别名:
V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; B7h.5; Immune Costimulatory Protein B7-H4; T Cell Costimulatory Molecule B7x; Protein B7S1
产品描述:
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
宿主来源:
CHO cells
保存温度:
+4°C
运输温度:
BI
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Measured by its ablility to inhibit anti-CD3-induced proliferation of stimulated mouse T cells.
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
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