BAFF, Soluble (human) (60-mer) (rec.) (highly active) MultiPack-其他重组蛋白-深圳欣博盛生物科技有限公司

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BAFF, Soluble (human) (60-mer) (rec.) (highly active) MultiPack

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0112-3010	规格：3 x 10 ug	目录价：￥6240
货号：AG-40B-0112-C010	规格：10 ug	目录价：￥3120

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

BAFF, Soluble (human) (60-mer) (rec.) (highly active) MultiPack

别名:

BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B; Tumor Necrosis Factor Ligand Superfamily Member 13B

产品描述:

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerization of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.

宿主来源:

E. coli

靶标/特异性:

Binds to human and mouse BAFF-R, TACI and BCMA. Relative binding affinity (EC50) for BAFF-R (human): ~3ng/ml.

产品浓度:

0.1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~19kDa (under reduced conditions)~1100kDa (under native conditions)

产品形式:

solid

存储溶液:

Lyophilized. Contains PBS.

有效期:

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

产地:

瑞士

纯度:

>95% (SDS-PAGE)

生物活性:

Increases B cell survival/proliferation. Increases CD21/CD23 expression on B cells in vivo. Activates BAFF-R, TACI and BCMA receptors. Works at concentrations <20ng/ml.

内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).

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