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折扣/货期| 货号：GTX26300 | 规格：100μl | 目录价：￥5100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
beta Catenin antibody [6F9]
别名:
catenin beta 1 , CHBCAT
反应种属:
Bovine, Chicken, Dog, Human, Mouse
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-Fr, WB
靶标/特异性:
The antibody does not cross-react with plakoglobin (γ-catenin).
同种型:
IgG1
免疫原:
recombinant chicken β-catenin.
克隆性:
Monoclonal
克隆号:
6F9
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 protooncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
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