Beta-Lapachone-抑制剂-深圳欣博盛生物科技有限公司

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Beta-Lapachone

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-589-25MG

规格：25 mg

目录价：￥4536

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Beta-Lapachone

别名:

3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; NSC-26326

产品描述:

DNA topoisomerase I inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

242.3

产品形式:

Orange powder

产地:

加拿大

功能与背景:

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action (1). Induces apoptosis in a number of cancer cell lines (2). In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms (3) resulting in the production of reactive oxygen species (4). Suppresses radiation-induced activation of NFĸB (5). Attenuates cognitive impairment and inflammation in amyloid-induced mouse model.

纯度:

>98% (HPLC); NMR (Conforms)

来源:

Synthetic

CAS号:

4707-32-8

分子式:

C15H14O3

溶解度:

May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml)

PubChem CID:

3885