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折扣/货期| 货号：SIH-589-5MG | 规格：5 mg | 目录价：￥1252.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Beta-Lapachone
别名:
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; NSC-26326
产品描述:
DNA topoisomerase I inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
242.3
产品形式:
Orange powder
产地:
加拿大
功能与背景:
β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. A novel DNA topoisomerase I inhibitor which unlike camptothecin
does not stabilize the cleavable complex indicating a novel mode of action (1). Induces apoptosis in a number of cancer cell lines (2). In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms (3) resulting in the production of reactive oxygen species (4). Suppresses radiation-induced activation of NFĸB (5). Attenuates cognitive impairment and inflammation in amyloid-induced mouse model.
纯度:
>98% (HPLC); NMR (Conforms)
来源:
Synthetic
CAS号:
4707-32-8
分子式:
C15H14O3
溶解度:
May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml)
PubChem CID:
3885
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