官网链接
折扣/货期| 货号：GTX70113 | 规格：100μl | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
BRCA1 antibody [8F7]
别名:
BRCA1 DNA repair associated , BRCAI , BRCC1 , BROVCA1 , FANCS , IRIS , PNCA4 , PPP1R53 , PSCP , RNF53
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
IHC, IHC-P, IP, WB
靶标/特异性:
This antibody recognizes full-length BRCA1, a 220-kDa nuclear phosphoprotein. Mutations in this tumor suppressor gene greatly increase the risk of breast cancer.,KO/KD validation is based on published data (PMID: 23805307).
同种型:
IgG1
免疫原:
Protein fragment expressed in E. coli corresponding to amino acids 341-748.
克隆性:
Monoclonal
克隆号:
8F7
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
208
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
您可能感兴趣的产品
Chk1 (phospho Ser317) antibody [HL4313]
货号：GTX643560
SLC25A1 antibody [HL4228]
货号：GTX643061
Latrophilin 2 antibody [HL4090]
货号：GTX642529
PSD93 antibody [GT126]
货号：GTX642326
PRRS virus Nucleocapsid protein antibody [GT119]
货号：GTX642224
CXCL10 / IP10 antibody [HL3871]
货号：GTX642109
Klotho antibody [HL3707]
货号：GTX641879
CXCR5 antibody [HL3568]
货号：GTX641474
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询