c-Abl (phospho Tyr245) antibody-多抗-深圳欣博盛生物科技有限公司

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c-Abl (phospho Tyr245) antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX24479

规格：50μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

c-Abl (phospho Tyr245) antibody

别名:

ABL proto-oncogene 1, non-receptor tyrosine kinase , ABL , CHDSKM , JTK7 , bcr/abl , c-ABL , c-ABL1 , p150 , v-abl

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ICC/IF, WB

靶标/特异性:

This antibody is raised against human c-Abl (isoform b) phosphorylated at Tyr245. Based on sequence homology, it is predicted to react with c-Abl (isoform a) and ABL2 when phosphorylated at the corresponding residues - c-Abl (isoform a) Tyr226 or ABL2 Tyr272.

同种型:

IgG

免疫原:

synthesized phosphopeptide derived from a region of human c-Abl that contains tyrosine 245

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified IgG

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

123

产品形式:

Liquid

存储溶液:

PBS, 0.1% BSA, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

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