c-Kit antibody [ACK2] (APC-Cy7)-单抗-深圳欣博盛生物科技有限公司

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c-Kit antibody [ACK2] (APC-Cy7)

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01469-15

规格：100μg

目录价：￥4100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

c-Kit antibody [ACK2] (APC-Cy7)

产品描述:

The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo.

反应种属:

Mouse

宿主来源:

Rat

实验应用:

FCM

同种型:

IgG2b

克隆性:

Monoclonal

克隆号:

ACK2

纯化方式:

Purified by affinity chromatography

偶联:

APC-Cy7

产品浓度:

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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