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折扣/货期| 货号：GTX01469 | 规格：100μg | 目录价：￥2000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
c-Kit antibody [ACK2]
产品描述:
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo.
反应种属:
Human, Mouse, Rat
宿主来源:
Rat
实验应用:
Depletion, FCM, ICC/IF, IHC-P
同种型:
IgG2b
克隆性:
Monoclonal
克隆号:
ACK2
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
10mM NaH₂PO₄, 150mM NaCl, 0.09% Sodium azide.
产地:
美国
生产商:
GeneTex
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