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折扣/货期| 货号：SPC-182B | 规格：200 µg | 目录价：￥4901.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Calnexin-CT Antibody
别名:
Calnexin antibody, CALX_HUMAN antibody, CANX antibody, CNX antibody, FLJ26570 antibody, Histocompatibility complex class I antigen binding protein p88 antibody, IP90 antibody, Major histocompatibility complex class I antigen-binding protein p88 antibody, P90 antibody
产品描述:
Rabbit Anti-Dog Calnexin-CT Polyclonal
反应种属:
Human | Mouse | Rat | Bovine | Monkey | Chicken | Dog | Guinea Pig (Cavia porcellus) | Hamster | Pig | Avian | Quail | Rabbit | Sheep | Fruit Fly (Drosophila melanogaster) | African clawed frog (Xenopus laevis)
宿主来源:
Rabbit
实验应用:
WB | IHC | ICC/IF | IP | FCM
靶标/特异性:
Detects the C-terminal domain of Calnexin ~90kDa. Weak detection in Chicken, Drosophila, and Xenopus tissues.
推荐稀释度:
WB (1:2000), ICC/IF (1:100), IHC (1:100); optimal dilutions for assays should be determined by the user.
免疫原:
Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
免疫原种属:
Dog
克隆性:
Polyclonal
纯化方式:
Peptide Affinity Purified
偶联:
Unconjugated
产品浓度:
1 mg/ml
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
Accession #:
NP_001003232.1
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