Caspase 8 antibody [EPR162]-单抗-深圳欣博盛生物科技有限公司

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Caspase 8 antibody [EPR162]

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX63075

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Caspase 8 antibody [EPR162]

别名:

caspase 8 , ALPS2B , CAP4 , Casp-8 , FLICE , MACH , MCH5

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ICC/IF, IHC-P, WB

同种型:

IgG

免疫原:

Synthetic peptide corresponding to human Caspase-8 aa 200-300 (internal sequence).

克隆性:

Monoclonal

克隆号:

EPR162

纯化方式:

Tissue culture supernatant

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 50% Glycerol, 0.05% BSA, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

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