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折扣/货期| 货号：GTX10450 | 规格：100μl | 目录价：￥6600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Caspase 8 antibody
别名:
caspase 8 , ALPS2B , CAP4 , Casp-8 , FLICE , MACH , MCH5
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
By immunoblotting, the antibody reacts with caspase 8a (55 kDa) and caspase 8b (54 kDa) and weakly cross-reacts with MACHβ3/MACHβ4 isoforms (30-32 kDa).
同种型:
IgG
免疫原:
synthetic peptide corresponding to amino acids 209-224 of the human caspase 8a/MACHα1 precursor, conjugated to KLH. The sequence contains the N-terminal region of the enzyme p18 subunit and is identical in other human caspase 8 isoforms (caspase 8b/MACHα2, MACHβ3, MACHβ4) and highly conserved (>85%) in mouse caspase 8.
克隆性:
Polyclonal
克隆号:
纯化方式:
IgG fraction
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
55
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase_x005f_x0013_9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
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