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折扣/货期| 货号：GTX73092 | 规格：500μl | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Caspase 8 antibody
别名:
caspase 8 , ALPS2B , CAP4 , Casp-8 , FLICE , MACH , MCH5
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
IHC-P, IP, WB
靶标/特异性:
It is recommended for detection of the p18 subunit and precursor of caspase-8 of mouse, rat and human origin.
同种型:
IgG
免疫原:
The epitope corresponding to amino acids 217-350 mapping within the caspase-8 p18 subunit of human origin.
克隆性:
Polyclonal
克隆号:
纯化方式:
Protein A affinity purified
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.2% BSA, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
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