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折扣/货期| 货号：GTX21673 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CCR5 antibody
别名:
CC motif chemokine receptor 5 (gene/pseudogene),CCCKR5,CCR5,CD195,CKR5,CMKBR5,IDDM22,C-C motif chemokine receptor 5 (gene/pseudogene)
反应种属:
Human, Macaque
宿主来源:
Goat
实验应用:
ELISA, IHC, IHC-P, WB
同种型:
IgG
免疫原:
Synthetic peptide 3YQVSSPIYDINYYTSEPCQKINVKQIAA30 corresponding to the N-terminal sequence of human CCR5
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
41
产品形式:
Liquid
存储溶液:
10mM KHPO₄, 140mM NaCl, 0.1% BSA, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
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