CD152 [CTLA-4] (human):Fc (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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CD152 [CTLA-4] (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HF-210A4-C100	规格：100 ug	目录价：￥1400
货号：CHI-HF-210A4-C500	规格：500 ug	目录价：￥3780

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD152 [CTLA-4] (human):Fc (human) (rec.)

别名:

CTLA-4

产品描述:

CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.

宿主来源:

CHO cells

保存温度:

+4°C

运输温度:

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

产地:

瑞士

纯度: