CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HF-210PDL1-C100

规格：100 ug

目录价：￥5040

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD274 [B7-H1/PD-L1] (human):Fc (human) (rec.)

别名:

PD-L1; Programmed Cell Death 1 Ligand Protein 1; PDCD1 Ligand 1; B7-H1; PDL1

产品描述:

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

宿主来源:

CHO cells

保存温度:

+4°C

运输温度:

预期分子量:

~54kDa (monomer)

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

有效期: