CD279 [PD-1] (human):Fc (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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CD279 [PD-1] (human):Fc (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HF-210PD1-C100

规格：100 ug

目录价：￥5740

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD279 [PD-1] (human):Fc (human) (rec.)

别名:

PD-1; Programmed Cell Death Protein 1

产品描述:

CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

宿主来源:

CHO cells

保存温度:

+4°C

运输温度:

预期分子量:

~50-70kDa

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

产地:

瑞士

纯度:

>98% (SDS-PAGE)

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized rhPDL1-His at 20µg/ml (50µl/well) binds to rhPD1-Fc (CHI-HF-210PD1) with an EC50 of ~1.2µg/ml.

内毒素水平:

<1EU/mg protein (LAL test; Lonza).

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