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折扣/货期| 货号：CHI-MF-110PD1-C100 | 规格：100 ug | 目录价：￥5040 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD279 [PD-1] (mouse):Fc (mouse) (rec.)
别名:
PD-1; Programmed Cell Death Protein 1
产品描述:
CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
宿主来源:
CHO cells
保存温度:
+4°C
运输温度:
BI
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
内毒素水平:
<0.06EU/µg protein (LAL test; Lonza).
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